D&C Yellow No. 10 (CI 47005) | Substance (2024)

EFSA notes there is equivocal evidence of genotoxiciy.

some

European Food Safety Authority (EFSA). 2009. Scientific Opinion on the re‐evaluation of Quinoline Yellow (E 104) as a food additive. EFSA Journal 7(11), 1329.

EFSA concludes there is limited evidence that Yellow 10 in a mixture with other synthetic colours and sodium benzoate has a "small and statistically significant effect on activity and attention in children selected from the general population".

some

European Food Safety Authority (EFSA). 2009. Scientific Opinion on the re‐evaluation of Quinoline Yellow (E 104) as a food additive. EFSA Journal 7(11), 1329.

EFSA finds that developmental effects have been observed in animal tests.

some

European Food Safety Authority (EFSA). 2009. Scientific Opinion on the re‐evaluation of Quinoline Yellow (E 104) as a food additive. EFSA Journal 7(11), 1329.

Very toxic to aquatic life

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Very toxic to aquatic life with long lasting effects

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Suspected of causing genetic defects

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Suspected of causing cancer

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Causes damage to organs through prolonged or repeated exposure

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Very toxic to aquatic life

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Known to cause cancer

some

California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)

Suspected of causing genetic defects

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

May cause cancer

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Causes damage to organs through prolonged or repeated exposure

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Very toxic to aquatic life

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Very toxic to aquatic life with long lasting effects

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Fatal if inhaled

Only in: Household Cleaners

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Suspected of damaging fertility.

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Suspected of damaging the unborn child.

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Carcinogenic to humans

some

International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)

Known To Be Human Carcinogen

some

National Toxicology Program (NTP): NTP 14th Report on Carcinogens

Probably carcinogenic to humans

some

Environmental Protection Agency (EPA): EPA Integrated Risk Information System (IRIS) - Cancer

Probably carcinogenic to humans

some

International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)

Probably carcinogenic to humans

some

Environmental Protection Agency (EPA): EPA Integrated Risk Information System (IRIS) - Cancer

A review article reports equivocal evidence of genotoxicity, including in human cell assays.

some

Peer Reviewed Literature: Amchova, P., H. Kotolova & J. Ruda-Kucerova. 2015. Health safety issues of synthetic food colorants. Regulatory toxicology and pharmacology : RTP 73(3), 914-22.

A review article reports equivocal evidence of genotoxicity, including in human cell assays.

some

Peer Reviewed Literature: Amchova, P., H. Kotolova & J. Ruda-Kucerova. 2015. Health safety issues of synthetic food colorants. Regulatory toxicology and pharmacology : RTP 73(3), 914-22.

Toxic if swallowed

Only in: Household Cleaners

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Toxic in contact with skin

Only in: Household Cleaners

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Toxic if inhaled

Only in: Household Cleaners

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

kidney damage

some

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

suspected human carcinogen

some

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

A peer-reviewed study reports endocrine activity in cellular assays.

some

Patrick Tarnow, Catrin Zordick, Alex Bottke, Berit Fischer, Friederike Kühne, Tewes Tralau & Andreas Luch. 2020. Characterization of Quinoline Yellow Dyes As Transient Aryl Hydrocarbon Receptor Agonists. Chemical research in toxicology 33(3), 742-750.

Suspected of damaging fertility or the unborn child

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

suspected of causing genetics defects

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

causes damage to organs through prolonged or repeated exposure

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

EFSA notes that Yellow 10 intolerance/sensitivity have been reported.

some

European Food Safety Authority (EFSA). 2009. Scientific Opinion on the re‐evaluation of Quinoline Yellow (E 104) as a food additive. EFSA Journal 7(11), 1329.

confirmed animal carcinogen with unknown relevance to humans

some

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

May cause an allergic skin reaction

Only in: Household Cleaners

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

NTP Toxcast scored 1.5-2.5

some

National Toxicology Program (NTP): EWG Toxcast Analysis

NTP Toxcast scored 1.5-2.5

some

National Toxicology Program (NTP): EWG Toxcast Analysis

Toxic in contact with skin

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

toxic if inhaled

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

Toxic of swallowed

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

SCCS notes there is limited evidence of skin irritation.

some

European Commission, Scientific Committee on Consumer Safety (SCCS). 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS Concerning Acid Yellow 3.

Causes serious eye damage

Only in: Drain Opener/Clog Remover; Oven Cleaner; Household Cleaners

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Harmful if swallowed

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

harmful in inhaled

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

may cause damage to organs through prolonged or repeated exposure

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

May cause an allergic skin reaction

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

may cause respiratory irritation

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

May cause an allergic skin reaction

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

may cause respiratory irritation

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

Causes serious eye damage

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

Causes skin irritation

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

Causes skin irritation

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

Causes serious eye damage

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

causes serious eye irritation

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

causes serious eye irritation

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

SCCS notes there is limited evidence of eye irritation.

low

European Commission, Scientific Committee on Consumer Safety (SCCS). 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS Concerning Acid Yellow 3.

Not classifiable as to human carcinogenicity

low

Environmental Protection Agency (EPA): EPA Integrated Risk Information System (IRIS) - Cancer

Not known to cause asthma

low

Association of Occupational and Environmental Clinics (AOEC): AOEC Exposure Code List (2020 Update)

Not classifiable as to its carcinogenicity to humans

low

International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)

EPA testing shows this substance has moderate acute toxicity to aquatic life

low

Environmental Protection Agency (EPA): EPA Fathead Minnow Acute Toxicity Database

No evidence of skin sensitization in limited human and animal tests.

low

European Commission, Scientific Committee on Consumer Safety (SCCS). 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS Concerning Acid Yellow 3.

EPA testing shows this substance has low acute toxicity to aquatic life

low

Environmental Protection Agency (EPA): EPA Fathead Minnow Acute Toxicity Database

Low acute oral toxicity in animal studies.

low

European Commission, Scientific Committee on Consumer Safety (SCCS). 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS Concerning Acid Yellow 3.

D&C Yellow No. 10 (CI 47005) | Substance (2024)

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